TASIN-1 Hydrochloride

CAS No. 1678515-13-3

TASIN-1 Hydrochloride ( TASIN 1 Hydrochloride; TASIN1 Hydrochloride; TASIN-1 HCl; TASIN 1 HCl; TASIN1 HCl )

Catalog No. M27797 CAS No. 1678515-13-3

TASIN-1 Hydrochloride is a selective inhibitor of truncated APC that acts by selectively killing colorectal cancer cells that express truncated APC by reducing cellular cholesterol levels and inducing apoptotic cell death through the ER stress/ROS/JNK signaling in colon cancer cells.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 219 Get Quote
10MG 311 Get Quote
25MG 530 Get Quote
50MG 755 Get Quote
100MG 1044 Get Quote
500MG 2097 Get Quote
1G Get Quote Get Quote

Biological Information

  • Product Name
    TASIN-1 Hydrochloride
  • Note
    Research use only, not for human use.
  • Brief Description
    TASIN-1 Hydrochloride is a selective inhibitor of truncated APC that acts by selectively killing colorectal cancer cells that express truncated APC by reducing cellular cholesterol levels and inducing apoptotic cell death through the ER stress/ROS/JNK signaling in colon cancer cells.
  • Description
    TASIN-1 Hydrochloride is a selective inhibitor of truncated APC that acts by selectively killing colorectal cancer cells that express truncated APC by reducing cellular cholesterol levels and inducing apoptotic cell death through the ER stress/ROS/JNK signaling in colon cancer cells.(In Vitro):In two authentic human CRC cell lines HCT116 (WT APC) and DLD1 (truncated APC1417), TASIN-1 exhibited potent and selective toxicity toward DLD1 cells (IC50: 70 nM but not toward HCT116 cells (IC50 >50 μM)). TASIN-1 also reduced the endogenous cholesterol biosynthesis rate. TASIN-1 exerted its killing effects primarily by depleting cholesterol through inhibition of emopamil-binding protein (EBP) activity. However, knockdown of truncated APC (>90%) expression desensitized DLD1 cells to TASIN-1, suggesting that APC is required for TASIN-1’s cytotoxicity.(In Vivo):In nude mice with established DLD1 and HT29 tumors, intraperitoneal injection of TASIN-1 twice daily for 18 days reduced the size of tumor xenografts and tumor growth rates. TASIN-1 resulted in the appearance of apoptotic cells with fragmented nuclei and induced an increase in cleaved caspase 3 and cleaved PARP1. However, TASIN-1 did not inhibit tumor growth in HCT116 xenografts. In a genetically engineered CRC mouse model, TASIN-1 significantly reduced tumor formation in the colons of CPC .
  • Synonyms
    TASIN 1 Hydrochloride; TASIN1 Hydrochloride; TASIN-1 HCl; TASIN 1 HCl; TASIN1 HCl
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    Ca(2+) receptor
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1678515-13-3
  • Formula Weight
    389.0
  • Molecular Formula
    C18H29ClN2O3S
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    Cl.COc1ccc(cc1)S(=O)(=O)N1CCC(CC1)N1CCC(C)CC1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Sewing KF, et al. Calcium channel antagonists verapamil and gallopamil are powerful inhibitors of acid secretion in isolated and enriched guinea pig parietal cells. Pharmacology. 1983;27(1):9-14.
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